Outcomes after resection of occupational cholangiocarcinoma

Cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane is recognised as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease. Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated. Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in 9 patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumours in 5 patients developed at a different part of the bile duct from the primary tumour and a second resection was performed in 4 of these 5 patients. The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.

Authors: Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Hamano G, Ito T, Koda M, Aota T, Yamamoto T, Terajima H, Tachiyama G, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Tomimaru Y, Sugawara Y, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Kimura K, Shirabe K, Saiura A, Uesaka K, Taniguchi H, Fukuda A, Chong JM, Kuwae Y, Ohsawa M, Sato Y, Nakanuma Y. ;Full Source: Journal of Hepato-Biliary-Pancreatic Sciences. 2016 Jul 1. doi: 10.1002/jhbp.373. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]