Phenol concentrations during childhood and subsequent measures of adiposity among young girls

Phenolic compounds represent a class of environmental chemicals with potential endocrine disrupting capabilities. The present study investigated longitudinal associations of childhood exposures to phenols, from both man-made and natural sources, and subsequent measures of adiposity among girls enrolled in The Breast Cancer and Environment Research Program, 2004-2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan. Body mass index, waist circumference, and percent body fat were measured at annual or semi-annual exams through 2015 (n = 1,017). Linear mixed effects regression estimated how baseline concentrations of phenols (tertile groups) related to changes in girls’ adiposity measurements from ages 7 through 15 years. Enterolactone was inversely associated with body mass index, waist circumference, and percent body fat, while 2,5-dichlorophenol was positively associated with these measurements. A non-monotonic association was observed for triclosan and girls’ adiposity; however, it was due to effect modification by baseline overweight status. Triclosan was positively associated with adiposity only among overweight girls. The authors concluded that these results suggest that exposure to specific phenols during childhood may influence adiposity through adolescence.

Authors: Deierlein AL, Wolff MS, Pajak A, Pinney SM, Windham GC, Galvez MP, Rybak M, Calafat AM, Kushi LH, Biro FM, Teitelbaum SL; and the Breast Cancer and Environment Research Program ;Full Source: American Journal of Epidemiology. 2017 May 19. doi: 10.1093/aje/kwx136. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]