Polychlorinated biphenyls (PCBs), a class of synthetic organochlorine chemicals, were broadly employed in industrial and commercial applications in the last century due to their good thermal and chemical stability. However, PCBs have a great influence on both individual organism and the entire ecosystem. It has been proven that PCBs pose potential risks to human health with neurotoxicity, carcinogenicity, reproductive toxicity, immunotoxicity, hepatotoxicity, and cardiovascular toxicity. Moreover, PCBs exhibit the long-range transport effect on the global scale and bio-enrichment effect along the food chains. This review mainly encompasses recent progress on the toxicity and detection techniques of PCBs in environment and foodstuffs. First of all, we highlighted the latest improvements and achievements of the classification, source, distribution, and toxicity of PCBs. Then, comprehensive summaries of the current technologies for sample preparation (e.g., SPE, DSPE, SPME and SBSE) and analytical determination (e.g., GC-ECD, GC-MS, GC-HRMS, HPLC-MS/MS and sensing technologies) were given. In the end, the shortcomings and prospects of the pretreatment methods for PCBs analysis as well as the future opportunities and challenges are tentatively discussed.
Authors: Jin Liu, Guoliang Li, Jianghua Liu, Panxue Wang, Di Wu, Xianlong Zhang, Yongning Wu
; Full Source: Critical reviews in analytical chemistry 2022 Jan 28;1-26.