Relationships Between Urinary Phthalate Metabolite and Bisphenol A Concentrations and Vitamin D Levels in U.S. Adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010

Recent research suggests that environmental exposure to endocrine-disrupting chemicals may alter circulating 25-hydroxyvitamin D [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][25(OH)D] levels in humans. To date, no studies have assessed the associations between phthalates and bisphenol A (BPA) and total 25(OH)D in the U.S. general population. This study was undertaken to explore relationships between urinary concentrations of 11 phthalate metabolites and BPA and serum total 25(OH)D in a representative sample of U.S. adults. DESIGN: A cross-sectional study. SETTING: U.S. National Health and Nutrition Examination Survey, 2005-2010. PATIENTS OR OTHER PARTICIPANTS: U.S. general adult population (aged ?20 years). INTERVENTIONS: None Main Outcome Measures: Serum total 25(OH)D measured by liquid chromatography-tandem mass spectrometry. RESULTS: Metabolites of di(2-ethylhexyl) phthalate (DEHP) were consistently inversely associated with total 25(OH)D in the overall study population and in gender-stratified models. In the overall population, the authors detected a significant inverse relationship for the molar sum of DEHP metabolites (?DEHP), where an interquartile range increase in ?DEHP was associated with a 1.90% decrease (95% confidence interval [CI], -3.64, -0.17) in total 25(OH)D. A positive association was detected for monoethyl phthalate. For BPA, a statistically significant inverse relationship was found in women, but not in men. In women, an interquartile range increase in urinary BPA was associated with a 3.71% decrease (95% CI, -6.41, -1.02) in total 25(OH)D. CONCLUSIONS: Overall, our results provide suggestive evidence that environmental exposure to phthalates and BPA may alter circulating levels of total 25(OH)D in adults. Future human and animal studies are required to resolve the direction, temporality, and impact of these relationships.

Authors: Johns LE, Ferguson KK, Meeker JD. ;Full Source: Journal of Clinical Endocrinology & Metabolism. 2016 Sep 20: jc20162134. [Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]