Carbon disulfide (CS2) is widely used as an organic solvent. However, there is little information available regarding the clinical manifestations and the pathological features of kidney injury caused by CS2. The current study aimed to describe the renal manifestations of a group of patients with long-term occupational exposure to CS2. Ten patients with long-term exposure to CS2 and visiting a single centre were enrolled, with their clinical features recorded. Renal biopsies were taken from all patients and their pathological findings were documented. All patients came from the same chemical fibre factory. Their mean age at enrolment was 36.9?±?2.4?years, and each patient had a CS2 exposure duration exceeding 10?years. 8 patients (80%) presented with proteinuria and none had hematuria. 2 patients (20%) had underlying hypertension and 5 (50%) had increased serum creatinine levels. Light microscopic examination of their renal biopsy specimens revealed diffuse mesangial cell proliferation and mesangial hyperplasia in all patients. Moreover, 3 patients (30%) had nodular hyperplasia, resembling the lesions of diabetic nephropathy. Variable degrees of tubular atrophy and interstitial infiltrations of lymphocytes and monocytes were observed in all patients. Similarly, Electron microscopic examination showed glomerular mesangial cell proliferation and mesangial hyperplasia. Immunopathological staining for IgA and IgG, complements, or hepatitis B markers (hepatitis B surface antigen and e antigen-antibody) are negative in all patients. The authors concluded that long-term occupational exposure to CS2 may be associated with renal injury, although the renal pathological features are often nonspecific.
Authors: Ou S, He H, Qu L, Wu W, Gan L, Liu J. ;Full Source: Nephrology (Carlton). 2016 Jul 14. doi: 10.1111/nep.12853. [Epub ahead of print] ;