The study conducted determined whether Meiliang Bay source of drinking water in Taihu Lake (MLB-SDW-THL) had biochemical effects on the mouse serum for predication of its risks on human and environmental health after a cyanobacteria bloom polluted in 2007. The method was water samples of MLB-SDW-THL were taken at N31.53 and E120.21 in March of 2010 and kept at 4°C for the experiment Measurement of 22 organic pollutants with DSQ II Single Quadruple GC/MS in selected ion monitoring (SIM) indicated that 11 of them were discovered in MLB-SDW-THL. Mouse Mus musculus were feed with MLB-SDW-THL for 90d under standard conditions. The eighteen serum biochemical parameters, the clinical parameters used in China hospitals, were measured by Automatic Biochemical Analytical /RerLi 600 and the parameter data of treated by One-Way ANOVA statistic approach. The results showed that among the measured eighteen serum biochemical parameters, six of the 18 parameter levels were decreased significantly including alanine transaminase (ALT, 57% lower), aspartate aminotransferase (AST, 36% lower); cystatin C (Cys C, 25% lower); triglycerol (TG, 79% lower); high density lipoprotein-cholesterol (HDL-C,12% lower); and lipase (LPS, 16% lower). It indicated that the MLB-SDW-THL had biochemical toxicities on the serum of mouse Mus musculus which might induce metabolical disorders, liver and kidney diseases, cardiovascular diseases, brain disorders, pancreas diseases and survival year reduced in the elderly people et al. The authors suggested that the biochemical risks might be mainly from PAHs and di-Bu phthalate discovered at least in MLB-SDW-THL, which should be controlled for protection of human and environmental health.