Safety of Live-Attenuated Influenza Vaccination in Cystic Fibrosis

Given the improved efficacy of the nasal live-attenuated influenza virus vaccine (LAIV) compared with the injectable vaccine in children, the authors aimed to determine its safety in individuals with cystic fibrosis (CF). A cohort of 168 study participants, aged 2 to 18 years with CF, vaccinated with LAIV between 1 October 2012, and 30 January 2013, was followed prospectively for 56 days after initial vaccination in 3 paediatric CF clinics across the province of Quebec. Days 0 to 28 post-LAIV were considered the at-risk period for all outcomes of interest, and days 29 to 56 post-LAIV were considered the non-at-risk period. Incident respiratory deteriorations were defined as an unscheduled medical visit, hospitalisation, or a new course of oral antibiotics for respiratory complaints. Using a self-controlled design, incidence rate ratios (IRR) were used to compare at-risk and non-at-risk periods. Comparing at-risk to non-at-risk periods, there was no significant increase in the rate of incident respiratory deteriorations (IRR, 0.72; 95% confidence interval, 0.11-4.27) or all-cause hospitalisations (IRR, 1.16; 95% confidence interval, 0.30-4.81). A greater proportion of participants reported experiencing at least 1 minor respiratory and/or systemic adverse event after immunisation during the at-risk period compared with the non-at-risk period (77% vs 54%, respectively). During the first week after LAIV, 13 of 168 (8%) children reported some wheezing, with the vast majority, 9 of 13 (69%), on the day of vaccination. the authors concluded that based on the findings, there was no increased risk of respiratory deterioration or all-cause hospitalisation associated with LAIV in our study population. LAIV seems well tolerated in children and adolescents with CF.

Authors: Boikos C, De Serres G, Lands LC, Boucher FD, Tapiéro B, Daigneault P, Quach C. ;Full Source: Pediatrics. 2014 Sep 15. pii: peds.2014-0887. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print] ;[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]