In this study, the authors investigated the effect of dimethylformamide (DMF) on liver injury of workers with exposure and occupational health surveillance plan, and the intervention of vitamin C on the liver injury of workers exposed to DMF was studied. A total of 240 male workers exposed to MDF were selected and divided into high exposure group A and B, low exposure group and placebo group, another 60 non-DMF exposed male workers were recruited as a control group. The research subjects were continuously administrated with vitamin C or starch for 3 months, and the serum biochemical indexes were detected once a month, as well as urine N-methylformamide (NMF) at the end of work shifts. After 3 months of medication, the rate of gastrointestinal symptoms of each group were 6.7% of the control group, 8.3% of the low concentration group, 20.0% of placebo group, 11.7% of the high concentration group A, 10.0% of the high concentration group B. That of the low concentration group and the high concentration of group B was lower after treatment (P<0.05), the rest was not significantly different. Urinary NMF levels of each group at the end of work shifts were 0 mg/L of control group, 5.4 mg/L of low concentration, 15.5 mg/L of placebo group, 16.3 mg/L of high concentration A, 8.8 mg/L high concentration B. The low concentration group, high concentrations group A and B was lower after treatment, the differences were significant (P<0.01). Rates of abnormal liver function in each group were 6.7% of control group, 8.3% of low-concentration group, 28.3% of placebo group, 16.7% of the high concentration group A, and 8.3% of the high concentration group B. In the low concentration group, high concentration group A and B, the differences were significant after treatment. (P<0.05). the authors concluded that the findings from this study suggest that DMF-induced acute liver injury in workers is linearly related to urinary NMF level, chronic liver injury may be related to A/G levels. Urinary NMF level can be used as a biological exposure limit for workers exposed to DMF. Adequate vitamin C can prevent the DMF-induced acute liver dysfunction.
Authors: Zhao, Linhui; Xiao, Wei; Jiang, Jinhua; Zhu, Shixin; Shi, Jian ;Zhiye Yu Jiankang 2011, 27(21), 2401-2405 (Chinese) ;