Study of health surveillance and intervention of vitamin C on workers exposed to dimethylformamide

In this study, the authors investigated the effect of dimethylformamide (DMF) on liver injury of workers with exposure and occupational health surveillance plan, and the intervention of vitamin C on the liver injury of workers exposed to DMF was studied. A total of 240 male workers exposed to MDF were selected and divided into high exposure group A and B, low exposure group and placebo group, another 60 non-DMF exposed male workers were recruited as a control group. The research subjects were continuously administrated with vitamin C or starch for 3 months, and the serum biochemical indexes were detected once a month, as well as urine N-methylformamide (NMF) at the end of work shifts. After 3 months of medication, the rate of gastrointestinal symptoms of each group were 6.7% of the control group, 8.3% of the low concentration group, 20.0% of placebo group, 11.7% of the high concentration group A, 10.0% of the high concentration group B. That of the low concentration group and the high concentration of group B was lower after treatment (P<0.05), the rest was not significantly different. Urinary NMF levels of each group at the end of work shifts were 0 mg/L of control group, 5.4 mg/L of low concentration, 15.5 mg/L of placebo group, 16.3 mg/L of high concentration A, 8.8 mg/L high concentration B. The low concentration group, high concentrations group A and B was lower after treatment, the differences were significant (P<0.01). Rates of abnormal liver function in each group were 6.7% of control group, 8.3% of low-concentration group, 28.3% of placebo group, 16.7% of the high concentration group A, and 8.3% of the high concentration group B. In the low concentration group, high concentration group A and B, the differences were significant after treatment. (P<0.05). the authors concluded that the findings from this study suggest that DMF-induced acute liver injury in workers is linearly related to urinary NMF level, chronic liver injury may be related to A/G levels. Urinary NMF level can be used as a biological exposure limit for workers exposed to DMF. Adequate vitamin C can prevent the DMF-induced acute liver dysfunction.

Authors: Zhao, Linhui; Xiao, Wei; Jiang, Jinhua; Zhu, Shixin; Shi, Jian ;Zhiye Yu Jiankang 2011, 27(21), 2401-2405 (Chinese) ;