In order to provide a quantitative risk evaluation for benzene-exposed workers, a quantitative method using PBPK model and dose-response model was applied to the carcinogenic risk evaluation for benzene-exposed workers. First, the internal dose of inhaled-benzene in human beings was simulated by exposure related dose estimating model recommended by USEPA. Then, the internal dose was substituted into the calculating formula of carcinogenic risk. In order to determine the uncertainty of the cancer risk, Monte-Carlo simulation (crystal ball) was used to analyse the risk probability distribution. Finally, a large petrochemical enterprise in Tianjin was selected as the case study and carcinogenic risk evaluation for benzene-exposed workers was calculated. The results show the benzene- exposed cancer risk obviously exceeds the maximum acceptable risk level 1×10-4, which suggest that it is necessary to take relevant measures to reduce risk.
Authors: Zhang, Qian; Liu, Mao; Huang, De-yin ;Full Source: Zhongguo Anquan Kexue Xuebao 2011, 21(5), 143-147 (Ch) ;