Surveillance of workplace contamination and occupational exposure to antineoplastic agents in a hospital setting: establishment of comprehensive monitoring methods for antineoplastic agents

An academic subcommittee of Japanese Society of Hospital Pharmacists formulated the guideline for the sterile preparation of antineoplastic agents in 2008. The practical methods to monitor a workplace contamination and occupational exposure to antineoplastic agents have not been introduced into a hospital setting yet. This study developed a monitoring method using doxorubicin for workplace contamination and occupational exposure to antineoplastic agents. The monitoring method was applied to survey the workplace contamination and occupational exposure to antineoplastic agents in Hamamatsu University Hospital. As the surveillance in a hospital setting, the flow line adhering to the guideline kept the exposure to low level. In addition, the occupational exposure in the workers was not observed. This method can be utilised to survey in a hospital setting. Contamination of the exterior surface of vials of cytostatic drugs by the drugs themselves is also a potential hazard to human health. This study developed a validated method using liquid chromatography-electrospray ionisation tandem mass spectrometry (LC-ESI-MS/MS) for the detection of contamination of the exteriors of vials of cisplatin and carboplatin. Randa injection (Nippon Kayaku Co., Ltd., Tokyo) for cisplatin and Paraplatin injection (Bristol-Myers Squibb, Tokyo) for carboplatin were selected as drug vials for the evaluation of external contamination. Amounts of 0.17-17.0 ng/vial as cisplatin and 0.48-794 ng/vial as carboplatin were detected from the exterior surface of the vials. The author concluded that this method using LC-ESI-MS/MS for the detection of platinum anticancer drugs is helpful for monitoring contamination of the exterior surface of drug vials.

Author: Naito, Takafumi ;Full Source: Yakugaku Kenkyu no Shinpo 2012, 28, 61-66 (Japanese) ;