Synthesis of nano-cuboidal gold particles for effective antimicrobial property against clinical human pathogens

Algae could offer a potential source of fine chemicals, pharmaceuticals and biofuels. In this study, a green synthesis of dispersed cuboidal gold nanoparticles (AuNPs) was achieved using red algae, Gelidium amansii reacted with HAuCl4. It was found to be 4-7 nm sized cubical nanoparticles with aspect ratio of 1.4 were synthesized using 0.5 mM of HAuCl4 by HRSEM analysis. The crystalline planes (111), (200), (220), (311) and elemental signal of gold was observed by XRD and EDS respectively. The major constitutes, galactose and 3,6-anhydrogalactose in the alga played a critical role in the synthesis of crystalline AuNPs with cubical dimension. Further, the antibacterial potential of synthesised AuNPs was tested against human pathogens, Escherichia coli and Staphylococcus aureus. The synthesised AuNPs found biocompatible up to 100 ppm and high concentration showed an inhibition against cancer cell. This novel report could be helped to exploration of bioresources to material synthesis for the application of biosensor and biomedical application.

Authors: Murphin Kumar PS, MubarakAli D, Saratale RG, Saratale GD, Pugazhendhi A, Gopalakrishnan K, Thajuddin N. ; Full Source: Microbial Pathogenesis. 2017 Oct 19; 113:68-73. doi: 10.1016/j.micpath.2017.10.032. [Epub ahead of print]