Dogs were frequently employed as laboratory subjects during the era of atomic bomb testing (1950-1980), particularly in studies used to generate predictive data regarding the expected effects of accidental human occupational exposure to radiation. The bulk of these studies were only partly reported in the primary literature, despite providing vital information regarding the effects of radiation exposure on a model mammalian species. Herein we review this literature and summarize the biological effects in relation to the isotopes used and the method of radionuclide exposure. Overall, these studies demonstrate the wide range of developmental and physiological effects of exposure to radiation and radionuclides in a mid-sized mammal.
Authors: Gabriella J Spatola, Elaine A Ostrander, Timothy A Mousseau
; Full Source: Biological reviews of the Cambridge Philosophical Society 2021 May 13. doi: 10.1111/brv.12723.