The Effects of Occupational Exposure of Carbon Disulfide on Sexual Hormones and Semen Quality of Male Workers From a Chemical Fibre Factory

This study aimed to analyse the relationship between occupational CS2 exposure and reproductive impairments. Seventy-six CS2-exposed (9.73?±?2.76?mg/m) male workers and 94 unexposed workers were selected for study. Worker demographics were assessed with a customised questionnaire. Sexual hormones and sperm-related parameters were measured by biochemical or morphological analysis. The CS2-exposed workers had significantly higher serum levels of follicle-stimulating hormone (FSH) and luteinising hormone (LH), and lower levels of testosterone (T). Significant decrements were also identified in sperm viability and motility, chromatin, antioxidant capacity, mitochondrial membrane potential, mitochondrial membrane permeability transition pore (MPTP), and respiratory chain Complexes II and IV. The authors concluded that the data indicated that occupational CS2 exposure can exert deleterious effects on male sexual hormones and sperm quality, and mitochondrial dysfunction may play a vital role in this process.

Authors: Guo Y, Ma Y, Chen G, Cheng J. ;Full Source: Journal of Occupational & Environmental Medicine. 2016 Jul 12. [Epub ahead of print] ;