Acne vulgaris constitutes a major health, social and economic problem. Current epidemiological evidence suggests that the prevalence of acne is considerably higher in Westernised societies due to the influence of environmental factors. Endocrine disrupting chemicals, which exist ubiquitously in the environment, are able to alter hormonal and homeostatic systems. The present article investigates the effects of several endocrine disrupting chemicals either acting as agonists of the androgen receptors or elevating testosterone levels due to interference with enzymes and binding proteins. Exposure to these agents may lead to the stimulation of the androgen receptors on the pilosebaceous units resulting to excess sebum output and infundibular hyperkeratinisation. Since the pathways underlying the pathogenesis of acne are still being elucidated, endocrine disrupting chemicals may be key determinants, which in combination with other aetiological factors trigger the initiation and development of acne.
Authors: Mazioti MC, Markakis KP, Raptis AE. ;Full Source: Medical Hypotheses. 2015 Apr 18. pii: S0306-9877(15)00155-3. doi: 10.1016/j.mehy.2015.04.012. [Epub ahead of print] ;