The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer

Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a weighted network, constructed using chemical-chemical interaction information, to identify new chemicals related to two types of lung cancer: non-small lung cancer and small-cell lung cancer. Then, a randomisation test as well as chemical-chemical interaction and chemical structure information were utilised to make further selections. A final analysis of these new chemicals in the context of the current literature indicates that several chemicals are strongly linked to lung cancer.

Authors: Chen L, Yang J, Zheng M, Kong X, Huang T, Cai YD. ;Full Source: PLoS One. 2015 Jun 5;10(6):e0128696. doi: 10.1371/journal.pone.0128696. eCollection 2015. ;