Circulating zearalenone and its metabolites differ in women due to body mass index and food intake

The environmental oestrogen, zearalenone (ZEA), is found in the food supply from Fusarium fungal contamination in grains and sometimes used as a growth promoter for beef cattle. Long-term exposure to ZEA and its metabolites may present health risk due to higher oestrogenic activity. Serum ZEA metabolites were measured to determine the exposure and the association with food intake in 48 overweight/obese women (52?±?9 years). The free and conjugated ZEA indicated the highest detection rate of all the metabolites. Conjugated ZEA and total ZEA metabolites were lower (p?=?0.02) in overweight/obese than normal weight women, and free metabolites were either the same or showed a trend to be higher. In addition, those with highest (280-480?g/d) compared those with lowest (<115?g/d) meat consumption had higher conjugated serum ZEA metabolite concentrations (p?

Authors: Mauro T, Hao L, Pop LC, Buckley B, Schneider SH, Bandera EV, Shapses SA. ; Full Source: Food and Chemical Toxicology. 2018 Jun;116(Pt B):227-232. doi: 10.1016/j.fct.2018.04.027. Epub 2018 Apr 17.

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