Aluminium production can be referred to the category of industries of the increased health hazard for the workers. During technological process of receiving aluminium the air of a working zone is polluted by a large number of harmful substances. Workers are exposed to the complex of toxicants possessing a polytropic impact on the body. The most significant consequences are violations of different types of metabolism in the organism, including lipid metabolism. The purpose of the study is the investigation of the state of lipid metabolism in persons working in the production of aluminium. The object of research was 108 male workers of aluminium production suffering from occupational pathology of airways. The group of comparison was consisted of 103 men, apparently healthy, not exposed to toxicants. There was determined the content of the total cholesterol (TC), high and low-density lipoprotein cholesterol (HDLC and LDLC), triglycerides (TG), phospholipids (PL), atherogenic index (AI). Statistical processing was performed with the use of software «Statistica 6.0». There were established statistically significant differences of indices of lipid exchange in the persons occupied in aluminium production when related to the group of comparison. IA values in persons from the study group proved to be higher than in the comparison group, due to elevated levels of TC and LDLC. The TG and PL level was also higher. The values of IA, TC and TG in workers of aluminium production in more than 50% cases exceeded the reference values. The average concentration of HDL cholesterol in both groups did not differ and was above the lower reference boundary. Established features of lipid metabolism in workers of aluminium allow us to suggest the distinction in mechanisms of developing proatherogenic disorders from previously established ones for workers exposed to other chemicals. One of the causes of the shaping of these disorders can be oxidative stress, which in turn serves as a response to the exposure of complex of toxic substances to workers.
Authors: Kudaeva IV, Dyakovich OA, Masnavieva LB, Popkova OV, Abramatets EA. ; Full Source: Gig Sanit. 2016;95(9):857-60.