Genotoxic effects following exposure to air pollution in street vendors from a high-traffic urban area

Workers in several occupational environments are exposed to pollutants. Street vendors, for example, typically work in a high-traffic urban environment and are exposed to numerous air pollutants, including genotoxic substances emitted by motor vehicles. This study examined the genotoxic effects of exposure to air pollution. The authors conducted cytological analyses to assess frequencies of micronucleated (MN) and binucleated (BN) cells in a sample of exfoliated oral mucosa cells. Street vendors and control subjects in the city of Uberlândia, Minas Gerais, Brazil, were compare and quantitative information on exposure conditions were collected from all test subjects, including concentrations of particulate matter. The authors found street vendors to exhibit higher frequencies of MN cells compared to the control group. The effects of possible confounding variables on MN frequencies, namely the body mass index (BMI), age, as well as smoking and alcohol habits were evaluated. Multiple linear regression analysis found no significant effects of any of those variables. Our results suggest that continued exposure to air pollution from traffic represents a major source of genotoxicity and raises concerns regarding disease prevention not only in street vendors but also other groups of people working in urban environments.

Authors: Domingues ÉP, Silva GG, Oliveira AB, Mota LM, Santos VSV, de Campos EO Jr, Pereira BB. ; Full Source: Environmental Monitoring & Assessment. 2018 Mar 14;190(4):215. doi: 10.1007/s10661-018-6598-2.

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