A non-invasive phenotypic indicator of the rate of nicotine metabolism is nicotine metabolite ratio (NMR) defined as a ratio of two major metabolites of nicotine – trans-3′-hydroxycotinine/cotinine. The rate of nicotine metabolism has important clinical implications for the likelihood of successful quitting with nicotine replacement therapy (NRT). In this study, the authors evaluated NMR among Polish smokers. In a cross-sectional study of 180 daily cigarette smokers (42% men; average age 34.6?±?13.0), spot urine samples were collected and measured trans-3′-hydroxycotinine (3-HC) and cotinine levels with LC-MS/MS method. NMR (molar ratio) was calculated and analysed variations in NMR among groups of smokers. In the whole study group, an average NMR was 4.8 (IQR 3.4-7.3). The group of women below 51 years had significantly greater NMR compared to the rest of the population (6.4; IQR 4.1-8.8 vs. 4.3; IQR 2.8-6.4). No differences were found among group ages of male smokers. This is a first study to describe variations in nicotine metabolism among Polish smokers. The findings indicate that young women metabolise nicotine faster than the rest of population. This finding is consistent with the known effects of oestrogen to induce CYP2A6 activity. Young women may require higher doses of NRT or non-nicotine medications for most effective smoking cessation treatment.
Authors: Kosmider L, Delijewski M, Koszowski B, Sobczak A, Benowitz NL, Goniewicz ML. ; Full Source: Pharmacological Reports. 2017 Nov 22;70(3):434-438. doi: 10.1016/j.pharep.2017.11.009. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][Epub ahead of print][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]